The first synthetically fabricated osteoinductive bone graft
OSOPIA is a synthetic Biphasic Calcium Phosphate (BCP) manufactured using an innovative proprietary process that induces ectopic bone formation in muscle and epithelial tissues. Its main advantage over DFDBA is that it is mineralized (better remodelling properties). Its advantage over FDBA is that it is osteoinductive whereas FDBA is not.
Slow resorption profile providing continuous remodeling process for 100% vital bone.
Innovative surface technology inducing uniform bone ingrowth and active regeneration throughout the defect.
Synthetic graft concept designed for maximum product safety and performance.
OSOPIA can be used in following indications:
Filling of contained bone defects (e.g., after apicoectomy or cystectomy)
Filling of alveolar defects after tooth extraction (for ridge preservation or delayed implant placement >6 months)
Filling of periodontal bone defects (e.g. intrabony or furcation defects)
Filling of multiple-walled maxillofacial bone defects (e.g. cleft reconstruction)
Ridge augmentation (GBR: Guided Bone Regeneration)
Miron RJ, Sculean A, Shuang Y, Bosshardt DD, Gruber R, Buser D, Chandad F, Zhang Y. Osteoinductive potential of a novel biphasic calcium phosphate bone graft in comparison with autographs, xenografts, and DFDBA. Clin Oral Implants Res. 2016 Jun;27(6):668-75. doi: 10.1111/clr.12647. (IF = 3.624)
Miron RJ, Shuang Y, Bosshardt DD, Caballé-Serrano J, Chandad F, Zhang Y. Osteogenic gene array of osteoblasts cultured on a novel osteoinductive biphasic calcium phosphate bone grafting material. Clin Oral Investig. 2017 Apr;21(3):801-808. doi: 10.1007/s00784-016-1825-0. Epub 2016 Apr 23. (IF = 2.308)
Miron RJ, Zhang Q, Sculean A, Buser D, Pippenger BE, Dard M, Shirakata Y, Chandad F, Zhang Y. Osteoinductive potential of 4 commonly employed bone grafts. Clin Oral Investig. 2016 Nov;20(8):2259-2265. (IF = 2.308)
Zhang Y, Shuang Y, Zhou W, Fu H, Qian L, Miron RJ. Addition of a synthetically fabricated osteoinductive biphasic calcium phosphate bone graft to BMP2 improves new bone formation. Clin Implant Dent Relat Res. 2016 Dec;18(6):1238-1247. doi: 10.1111/cid.12384. Epub 2015 Oct 28. (IF = 2.939)